精雕细琢,直击软肋!抗体微雕的艺术让抗HER2治疗更上一层楼|奇点深度( 四 )



15.Brezski, R. J. & Georgiou, G. Immunoglobulin isotype knowledge and appli- cation to Fc engineering. Curr. Opin. Immunol. 40, 62–69 (2016).

16.Stavenhagen J B, Gorlatov S, Tuaillon N, et al. Fc optimization of therapeutic antibodies enhances their ability to kill tumor cells in vitro and controls tumor expansion in vivo via low-affinity activating Fcγ receptors[J]. Cancer research, 2007, 67(18): 8882-8890.

17.Nordstrom J L, Gorlatov S, Zhang W, et al. Anti-tumor activity and toxicokinetics analysis of MGAH22, an anti-HER2 monoclonal antibody with enhanced Fcγ receptor binding properties[J]. Breast Cancer Research, 2011, 13(6): 1-14.

18.Rugo H S, Im S A, Cardoso F, et al. Efficacy of margetuximab vs trastuzumab in patients with pretreated ERBB2-positive advanced breast cancer: a phase 3 randomized clinical trial[J]. JAMA oncology, 2021, 7(4): 573-584.





本文作者丨奇点糕

推荐阅读