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【基因|PCR Array在免疫炎症研究中的应用】
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细胞因子具有调节固有免疫和适应性免疫、血细胞生成、细胞生长、APSC多能细胞以及损伤组织修复等多种功能 ， 是炎症的关键调节因子 ， 在急性和慢性炎症中都有参与 。 了解细胞因子是如何参与调控的 ， 可以更准确地识别介导炎症的药物和针对炎症性疾病的治疗 。
细胞因子的种类繁多 ， 根据免疫反应的性质可以对细胞因子进行如下分类：
Pro-inflammatory signalling
另外不同细胞因子在不同的免疫细胞中 ， 其功能也是有所差异的：
| Interleukins | |||
| Cytokine | Main sources | Target cell | Major function |
| IL-1 | Macrophages B cells DCs | B cells NK cells T-cells | Pyrogenic pro-inflammatory proliferation and differentiation BM cell proliferation |
| IL-2 | T cells | Activated T and B cells NK cells | Proliferation and activation |
| IL-3 | T cells NK cells | Stem cells | Hematopoietic precursor proliferation and differentiation |
| IL-4 | Th cells | B cells T cells macrophages | Proliferation of B and cytotoxic T cells enhances MHC class II expression stimulates IgG and IgE production |
| IL-5 | Th cells | Eosinophils B-cells | Proliferation and maturation stimulates IgA and IgM production |
| IL-6 | Th cells macrophages fibroblasts | Activated B-cells plasma cells | Differentiation into plasma cells IgG production |
| IL-7 | BM stromal cells epithelial cells | Stem cells | B and T cell growth factor |
| IL-8 | Macrophages | Neutrophils | Chemotaxis pro-inflammatory |
| IL-9 | T cell | T cell | Growth and proliferation |
| IL-10 | T cell | B cells macrophages | Inhibits cytokine production and mononuclear cell function anti-inflammatory |
| IL-11 | BM stromal cells |
